Title:
免疫療法用抗体と連結させたＥＣＭ親和性ペプチドを用いてがんを処置するための方法および組成物
Document Type and Number:
Japanese Patent JP7419070
Kind Code:
B2
Abstract:
The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
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Inventors:
Hubbell Jeffrey A.
Jun Ishihara
Aka Ishihara
Kazuto Fukunaga
schwartz melody
Jun Ishihara
Aka Ishihara
Kazuto Fukunaga
schwartz melody
Application Number:
JP2019557434A
Publication Date:
January 22, 2024
Filing Date:
April 20, 2018
Export Citation:
Assignee:
THE UNIVERSITY OF CHICAGO
International Classes:
A61K39/395; A61K38/19; A61K39/00; A61K45/00; A61K47/64; A61P35/00; A61P37/04; C07K14/475
Domestic Patent References:
| JP2015527307A | ||||
| JP2003532681A |
Foreign References:
| WO2016054107A1 | ||||
| WO2017009842A2 | ||||
| WO2016054555A2 |
Other References:
Science,2014年,343,pp.885-888
The Journal of Biological Chemistry,1995年,270(18),pp.10822-10827
J Mol Biol.,2016年11月24日,2017, 429,pp. 32-47
Scientific Reports,2016年02月17日,6,18205, pp.1-14
The Journal of Biological Chemistry,1995年,270(18),pp.10822-10827
J Mol Biol.,2016年11月24日,2017, 429,pp. 32-47
Scientific Reports,2016年02月17日,6,18205, pp.1-14
Attorney, Agent or Firm:
Hatsushi Shimizu
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto