Title:
がんを処置するための方法および組成物
Document Type and Number:
Japanese Patent JP7189160
Kind Code:
B2
Abstract:
Embodiments are directed to: (i) neutrophil secreted factors that have the capacity to kill a broad range of cancer cells without affecting the viability of non-cancer cells. Two neutrophil killing factors have been identified by the inventors: (1) eosinophil cationic protein (ECP) and (2) neutrophil elastase (ELANE); or (ii) therapeutic compositions that include CD95 degrading polypeptide components and methods of treating cancer with the same.
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Inventors:
becker rev
Cui Chan
Cui Chan
Application Number:
JP2019569454A
Publication Date:
December 13, 2022
Filing Date:
June 15, 2018
Export Citation:
Assignee:
THE UNIVERSITY OF CHICAGO
International Classes:
A61K38/17; A61K38/48; A61K45/00; A61K47/51; A61P35/00; A61P43/00
Domestic Patent References:
| JP2004123679A | ||||
| JP2006500944A |
Foreign References:
| WO2016125330A1 |
Other References:
DE Lima, P. O. et al.,Effect of eosinophil cationic protein on human oral squamous carcinoma cell viability,Molecular and Clinical Oncology,2015年,Vol.3, No.2,p.353-356,doi:10.3892/mco.2014.477
Ho, A. S. et al.,Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers,Oncotarget,2014年,Vol.5, No.2,p.473-480,doi:10.18632/oncotarget.1631
Hadji, A. et al.,Death induced by CD95 or CD95 ligand elimination,Cell Reports,2014年,Vol.7, No.1,p.208-222,doi:10.1016/j.celrep.2014.02.035
Ho, A. S. et al.,Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers,Oncotarget,2014年,Vol.5, No.2,p.473-480,doi:10.18632/oncotarget.1631
Hadji, A. et al.,Death induced by CD95 or CD95 ligand elimination,Cell Reports,2014年,Vol.7, No.1,p.208-222,doi:10.1016/j.celrep.2014.02.035
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto