Title:
METHODS AND COMPOSITIONS FOR TREATMENT AND DIAGNOSIS OF FIBROSIS, TUMOR INVASION, ANGIOGENESIS, AND METASTASIS
Document Type and Number:
Japanese Patent JP2014210785
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compositions for preventing and treating various diseases associated with fibrosis comprising an inhibitor of lysyl oxidase like 2 (LOXL2), and to provide treatment methods and kits thereof.SOLUTION: Provided are compositions containing, as an inhibitor of LOXL2, anti-LOXL2 antibody or antigen binding fragments thereof, siRNA, shRNA or antisense polynucleotides, and methods for treating hepatic fibrosis, kidney fibrosis, pulmonary fibrosis, skin scarring and keloid, and related compositions and kits thereof.
Inventors:
SMITH VICTORIA
OGG SCOTT
VAN VLASSELAER PETER
BARRY VIVIAN E
MARSHALL DEREK
HOLZER ALISON KAY
RODRIGUEZ HECTOR
OYASU MIHO
MCCAULEY SCOTT ALAN
GARCIA CARLOS AURELIO
BIERMANN DONNA HIROKO TOKUOKA
OGG SCOTT
VAN VLASSELAER PETER
BARRY VIVIAN E
MARSHALL DEREK
HOLZER ALISON KAY
RODRIGUEZ HECTOR
OYASU MIHO
MCCAULEY SCOTT ALAN
GARCIA CARLOS AURELIO
BIERMANN DONNA HIROKO TOKUOKA
Application Number:
JP2014117893A
Publication Date:
November 13, 2014
Filing Date:
June 06, 2014
Export Citation:
Assignee:
GILEAD BIOLOGICS INC
International Classes:
A61K39/395; A61K31/713; A61K48/00; A61P1/16; A61P11/00; A61P13/12; A61P17/00; A61P43/00; C12N9/99
Domestic Patent References:
| JP5659014B2 | 2015-01-28 |
Other References:
JPN6015025827; Ａｋｉｒｉ Ｇ， ｅｔ ａｌ．: 'Ｌｙｓｙｌ ｏｘｉｄａｓｅ-ｒｅｌａｔｅｄ ｐｒｏｔｅｉｎ-１ ｐｒｏｍｏｔｅｓ ｔｕｍｏｒ ｆｉｂｒｏｓｉｓ ａｎｄ ｔｕｍｏｒ ｐｒｏｇｒｅｓｓｉｏｎ ｉｎ ｖｉｖｏ' Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．６３， Ｎｏ．７, 20030401, ｐ．１６５７-１６６６
JPN5010013110; ＰＥＩＮＡＤＯ ＨＥＣＴＯＲ: ＴＨＥ ＥＭＢＯ ＪＯＵＲＮＡＬ Ｖ２４ Ｎ１９, 200510, Ｐ３４４６-３４５８
JPN6011061205; 蛋白質 核酸 酵素 第４８巻，第４号, 20030310, ｐ．５４０-５４８
JPN6011061207; 現代医療 第３５巻，第７号, 20030710, ｐ．１６５３-１６５８
JPN6011061209; 医薬ジャーナル 第３９巻，増刊号, 20030201, ｐ．３０５-３１０
JPN6015025830; 鈴木 淳史， 谷口 英樹: '上皮-間葉転換 細胞の"衣替え"現象' 医学のあゆみ 第２１７巻，第５号, 20060429, ｐ．５３６-５３９
JPN6015025833; Ｋａｌｌｕｒｉ Ｒ， Ｎｅｉｌｓｏｎ ＥＧ: 'Ｅｐｉｔｈｅｌｉａｌ-ｍｅｓｅｎｃｈｙｍａｌ ｔｒａｎｓｉｔｉｏｎ ａｎｄ ｉｔｓ ｉｍｐｌｉｃａｔｉｏｎｓ ｆｏｒ ｆｉｂｒｏｓｉｓ' Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｉｎｖｅｓｔｉｇａｔｉｏｎ Ｖｏｌ．１１２， Ｎｏ．１２, 200312, ｐ．１７７６-１７８４
JPN5010013110; ＰＥＩＮＡＤＯ ＨＥＣＴＯＲ: ＴＨＥ ＥＭＢＯ ＪＯＵＲＮＡＬ Ｖ２４ Ｎ１９, 200510, Ｐ３４４６-３４５８
JPN6011061205; 蛋白質 核酸 酵素 第４８巻，第４号, 20030310, ｐ．５４０-５４８
JPN6011061207; 現代医療 第３５巻，第７号, 20030710, ｐ．１６５３-１６５８
JPN6011061209; 医薬ジャーナル 第３９巻，増刊号, 20030201, ｐ．３０５-３１０
JPN6015025830; 鈴木 淳史， 谷口 英樹: '上皮-間葉転換 細胞の"衣替え"現象' 医学のあゆみ 第２１７巻，第５号, 20060429, ｐ．５３６-５３９
JPN6015025833; Ｋａｌｌｕｒｉ Ｒ， Ｎｅｉｌｓｏｎ ＥＧ: 'Ｅｐｉｔｈｅｌｉａｌ-ｍｅｓｅｎｃｈｙｍａｌ ｔｒａｎｓｉｔｉｏｎ ａｎｄ ｉｔｓ ｉｍｐｌｉｃａｔｉｏｎｓ ｆｏｒ ｆｉｂｒｏｓｉｓ' Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｉｎｖｅｓｔｉｇａｔｉｏｎ Ｖｏｌ．１１２， Ｎｏ．１２, 200312, ｐ．１７７６-１７８４
Attorney, Agent or Firm:
Naoto Uchida
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