Title:
遺伝子,腫瘍及びウイルス感染の治療,並びにプログラムされた細胞死(アポプトーシス)を予防するための方法及び組成物
Document Type and Number:
Japanese Patent JP3974167
Kind Code:
B2
Abstract:
The present invention relates to methods of treatment of programmed cell death (apoptosis) through the use of the HSV-1 gene gamma134.5 or the product of its expression, ICP34.5. The gene and its expression have been demonstrated to be required for HSV-1 neurovirulence, and in particular, to act as an inhibitor of neuronal programmed cell death which allows for viral replication. Use of the gene therapy, or the protein itself, can be expected to result in inhibition of programmed cell death in various neurodegenerative diseases. This invention also relates to novel vectors for gene therapy, including modified herpes virus. Methods are presented for conducting assays for substances capable of mimicing, potentiating or inhibiting the expression of gamma134.5 or the activity of ICP34.5. Also, methods are disclosed for the treatment of tumorogenic diseases, including cancer, and for treatment of herpes and other viral infections using inhibitors of gamma134.5 expression or ICP34.5 activity.
Inventors:
Loisman, Bernard
Chew, johnny
Chew, johnny
Application Number:
JP51743993A
Publication Date:
September 12, 2007
Filing Date:
February 26, 1993
Export Citation:
Assignee:
Arch Development Corporation
International Classes:
A61K31/70; A61K35/76; A61K35/30; C12N15/09; A61K38/16; A61K39/245; A61K48/00; A61P25/00; A61P31/12; A61P35/00; C07H21/04; C07K14/035; C12N15/38; C12N15/869; G01N33/50; A61K38/00
Domestic Patent References:
| JP62257385A |
Foreign References:
| EP0453242A1 | ||||
| EP0476953A1 | ||||
| WO1992004050A1 |
Other References:
GELLER, A. I., et., Proc. Acad. Natl. Sci. USA, 87, pp.8950-8954 (1990)
CHOU, J., et al., Science, 250, pp.1262-1266 (1990)
CHOU, J., et al., Science, 250, pp.1262-1266 (1990)
Attorney, Agent or Firm:
Motohiro Kurauchi