Title:
連続的に染色した組織における、１つの細胞の分割を使用する多重化バイオマーカー定量用の方法及びコンピュータ可読媒体
Document Type and Number:
Japanese Patent JP6496709
Kind Code:
B2
Abstract:
Improved systems and methods for the analysis of digital images are provided. More particularly, the present disclosure provides for improved systems and methods for the analysis of digital images of biological tissue samples. Exemplary embodiments provide for: i) segmenting, ii) grouping, and iii) quantifying molecular protein profiles of individual cells in terms of sub cellular compartments (nuclei, membrane, and cytoplasm). The systems and methods of the present disclosure advantageously perform tissue segmentation at the sub-cellular level to facilitate analyzing, grouping and quantifying protein expression profiles of tissue in tissue sections globally and/or locally. Performing local-global tissue analysis and protein quantification advantageously enables correlation of spatial and molecular configuration of cells with molecular information of different types of cancer.
More Like This:
| WO/1999/061912 | MOLECULAR ROD AND USES |
| WO/2006/134379 | TRITYL DERIVATIVES FOR ENHANCING MASS SPECTROMETRY |
Inventors:
Santa Maria-Bread, Albert
Sarah Chan, Brion Darryl
Richer, Jens
Padfield, Dark Ryan
Can, ants
Bread
Bello, Musodik O
Jinty, Fiona Marie
Sevinsky, Christopher James
Lee, Chin
Rosney, Megan Pearl
Sarah Chan, Brion Darryl
Richer, Jens
Padfield, Dark Ryan
Can, ants
Bread
Bello, Musodik O
Jinty, Fiona Marie
Sevinsky, Christopher James
Lee, Chin
Rosney, Megan Pearl
Application Number:
JP2016509096A
Publication Date:
April 03, 2019
Filing Date:
April 17, 2014
Export Citation:
Assignee:
GENERAL ELECTRIC COMPANY
International Classes:
G01N33/48; G01N21/64; G01N33/483
Domestic Patent References:
| JP2010500655A |
Foreign References:
| US20130051650 | ||||
| US20110091081 | ||||
| US20120269418 |
Other References:
村尾 晃平、外5名,“遺伝子導入に伴う細胞の変化を見分ける”,電子情報通信学会誌,日本,社団法人電子情報通信学会,2004年 3月 1日,Vol.87, No.3,pp.187-194
S. Waheed et al.,"Computer Aided Histopathological Classification of Cancer Subtypes",Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, 2007.,米国,IEEE,2007年10月14日,pp.503-508
S. Waheed et al.,"Computer Aided Histopathological Classification of Cancer Subtypes",Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, 2007.,米国,IEEE,2007年10月14日,pp.503-508
Attorney, Agent or Firm:
Arakawa Satoshi