Title:
脳障害関連疾患の診断のためのマーカーの検出に関する方法
Document Type and Number:
Japanese Patent JP5019878
Kind Code:
B2
Abstract:
A method of diagnosis of a brain damage-related disorder or the possibility thereof in a subject suspected of suffering therefrom, or of prognosis or therapeutic follow-up of a brain damage-related disorder in a subject, which comprises detecting Nucleoside diphosphate kinase A, or a variant or mutant thereof, and optionally at least one further polypeptide, or a variant or mutant thereof, selected from A-FABP, E-FABP, H-FABP, B-FABP, PGP 9.5, GFAP, Prostaglandin D synthase, Neuromodulin, Neurofilament L, Calcyphosine, RNA binding regulatory subunit, Ubiquitin fusion degradation protein 1 homolog, Glutathione S tranferase P, Cathepsin D, DJ-1 protein, Peroxiredoxin 5 and Peptidyl-prolyl cis-trans isomerase A (Cyclophilin A), in a sample of body fluid taken from the subject.
Inventors:
Hochstrasse, Denny, Francois
Sanchez, Jean-Charles
Rescue, pierre
Aral roll
Sanchez, Jean-Charles
Rescue, pierre
Aral roll
Application Number:
JP2006526704A
Publication Date:
September 05, 2012
Filing Date:
September 20, 2004
Export Citation:
Assignee:
ELECTROPHORETICS LIMITED
International Classes:
G01N33/53; A61K39/395; C07K14/02; C07K14/16; G01N33/573; G01N33/68
Domestic Patent References:
| JP2003526788A | ||||
| JP2002530679A | ||||
| JP2003516541A |
Foreign References:
| WO2003016910A1 | ||||
| WO2001098468A1 |
Other References:
Maja Puchades, et al.,Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease,Molecular Brain Research,2003年,Vol. 118,140-146
Kurt Krapfenbauer, et al.,Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders,Brain Research,2003年,Vol. 967,152-160
Mark A. Wilson, et al.,The 1.1-Å resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Prkinson's disease,PNAS,2003年 8月 5日,Vol. 100, No. 16,9256-9261
Kurt Krapfenbauer, et al.,Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders,Brain Research,2003年,Vol. 967,152-160
Mark A. Wilson, et al.,The 1.1-Å resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Prkinson's disease,PNAS,2003年 8月 5日,Vol. 100, No. 16,9256-9261
Attorney, Agent or Firm:
Yoshiyuki Osuga