Title:
生体系のグループ内の疾病の生物学的プロファイルに対する多成分天然産物混合物の影響を決定するための方法、並びに天然産物に基づく医薬品の開発及び品質管理
Document Type and Number:
Japanese Patent JP4675896
Kind Code:
B2
Abstract:
The present invention provides a method for determining the impact of a multicomponent mixture on a biological profile of a disease comprising the steps of: (a) determining a biological profile of the disease by comparing the biological profile of a group with symptoms of the disease with the biological profile of a reference (or healthy) group, using a multivariate analysis; (b) determining the impact of a series of samples of the multicomponent mixture on the biological profile of the disease, in which respective samples the concentrations of various components differ, using a multivariate analysis; (c) determining the composition of the samples of the multicomponent mixture that have shown in step (b) an impact on the biological profile of the disease, using a multivariate analysis; (d) identifying within the compositions as determined in step (c) the effective components and their respective concentrations required for having an impact on the biological profile of the disease, using a multivariate analysis. The invention also provides a method for preparing a medicament for treating a disease, wherein the effective components as identified in step (d) are combined in the respective concentrations required for having an impact on the biological profile of the disease. The invention further provides a method for controlling the composition of a multicomponent mixture, wherein the concentrations of at least two components of the mixture are adjusted to ensure that the at least two components of the mixture have an impact on a biological profile of the disease.
Inventors:
One, May
Witkamp, Renger
Van der grief, yang
Witkamp, Renger
Van der grief, yang
Application Number:
JP2006525291A
Publication Date:
April 27, 2011
Filing Date:
September 03, 2004
Export Citation:
Assignee:
Netherlandse Organisatier Folde Toge Pastonatol Wettenchaperik Ondelso Ektienou
International Classes:
G01N30/86; G01N27/62; G01N30/88; G01N33/50; G16B25/10; G16H50/20; G16H70/60
Domestic Patent References:
| JP2000055912A |
Foreign References:
| US20030044846 | ||||
| US20030096309 | ||||
| WO2003017177A1 |
Attorney, Agent or Firm:
Mitsuo Matsui