Title:
増殖障害及び分化障害の治療に有用な化合物の同定方法
Document Type and Number:
Japanese Patent JP2008537115
Kind Code:
A
Abstract:
The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, FBP20, FBP21, FBP22, FBP23, FBP24, and FBP25, transgenic mice, knock-out mice, host-cell expression systems and proteins encoded by the nucleotides of the novel substrate-targeting subunits. The present invention relates to screening assays that use novel and known substrate-targeting subunits of ubiquitin ligases to identify potential therapeutic agents such as small molecules, compounds or derivatives and analogues of the novel and known ubiquitin ligases which modulate activity of the novel and known ubiquitin ligases for the treatment of proliferative and differentiative disorders, such as cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target ubiquitin ligases and their substrates for the treatment of proliferative and differentiative disorder.
Inventors:
Michele Pagano
Frank Mercurio
Weillin Kie
Antonia Lopez-Girona
Angelo Pestia Lori
Frank Mercurio
Weillin Kie
Antonia Lopez-Girona
Angelo Pestia Lori
Application Number:
JP2008506615A
Publication Date:
September 11, 2008
Filing Date:
April 11, 2006
Export Citation:
Assignee:
New York University
CELGENE CORPORATION
CELGENE CORPORATION
International Classes:
G01N33/50; A61K45/00; A61P17/02; A61P35/00; A61P35/02; A61P43/00; G01N33/15; G01N33/53; C12N15/09
Domestic Patent References:
| JP2000166542A | 2000-06-20 | |||
| JP2005502368A | 2005-01-27 | |||
| JP2001224380A | 2001-08-21 | |||
| JP2004531218A | 2004-10-14 |
Attorney, Agent or Firm:
Toru Ishikawa