Title:
後成的修飾の同定及びモニタリング方法
Document Type and Number:
Japanese Patent JP2009519039
Kind Code:
A
Abstract:
The present invention provides novel methods for identifying and monitoring epigenetic modifications, such as imprinted genes, using microarray based technology. Specifically, the invention detects imprinted genes by the presence of overlapping closed and open chromatin markers. The invention also discloses a method for detecting the loss of imprinting on a genome-wide scale, which is indicative of a variety of medical conditions. Diagnostic assays and chromatin structure markers for identifying gene imprinting and loss thereof are also disclosed.
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Inventors:
Green roland dee
Bjornsung Hans Tea
Feinberg Andrew P
Bjornsung Hans Tea
Feinberg Andrew P
Application Number:
JP2008545761A
Publication Date:
May 14, 2009
Filing Date:
December 13, 2006
Export Citation:
Assignee:
Nimburgen Systems Incorporated
International Classes:
C12Q1/68; C12M1/00; C12N15/09
Other References:
JPN6012022038; 蛋白質核酸酵素 第４３巻、第１４号, 1998, ｐｐ．２１０１-２１０８
JPN6012022040; 実験医学 第１８巻、第８号, 2000, ｐｐ．１０７６-１０８０
JPN6012022044; 実験医学 第２３巻、第１２号, 200507, ｐｐ．１９５２-１９５４
JPN6012022046; Ｇｅｎｏｍｉｃｓ Ｖｏｌ．８３, 2004, ｐｐ．３４９-３６０
JPN6012022049; Ｍｅｔｈｏｄｓ Ｖｏｌ．３１, 2003, ｐｐ．６７-７５
JPN6012022051; Ｃａｎｃｅｒ Ｒｅｓ． Ｖｏｌ．６２, 2002, ｐｐ．６４５６-６４６１
JPN6012022023; Ｍｏｌ． Ｃｅｌｌ． Ｂｉｏｌ． Ｖｏｌ．２５， Ｎｏ．１１, 200506, ｐｐ．４６５０-４６６１
JPN6012022025; Ｍｅｔｈｏｄｓ Ｖｏｌ．３１, 2003, ｐｐ．８３-８９
JPN6012022028; ＴＩＢＳ Ｖｏｌ．２２, 1997, ｐｐ．１２８-１３２
JPN6012022031; Ｎａｔｕｒｅ Ｇｅｎｅｔｉｃｓ Ｖｏｌ．３０， Ｎｏ．１, 2002, ｐｐ．７７-８０
JPN6012022034; ＰＮＡＳ Ｖｏｌ．１００， Ｎｏ．１１, 2003, ｐｐ．６３６４-６３６９
JPN6012022036; ＰＮＡＳ Ｖｏｌ．１０１， Ｎｏ．１９, 2004, ｐｐ．７３９８-７４０３
JPN6012022040; 実験医学 第１８巻、第８号, 2000, ｐｐ．１０７６-１０８０
JPN6012022044; 実験医学 第２３巻、第１２号, 200507, ｐｐ．１９５２-１９５４
JPN6012022046; Ｇｅｎｏｍｉｃｓ Ｖｏｌ．８３, 2004, ｐｐ．３４９-３６０
JPN6012022049; Ｍｅｔｈｏｄｓ Ｖｏｌ．３１, 2003, ｐｐ．６７-７５
JPN6012022051; Ｃａｎｃｅｒ Ｒｅｓ． Ｖｏｌ．６２, 2002, ｐｐ．６４５６-６４６１
JPN6012022023; Ｍｏｌ． Ｃｅｌｌ． Ｂｉｏｌ． Ｖｏｌ．２５， Ｎｏ．１１, 200506, ｐｐ．４６５０-４６６１
JPN6012022025; Ｍｅｔｈｏｄｓ Ｖｏｌ．３１, 2003, ｐｐ．８３-８９
JPN6012022028; ＴＩＢＳ Ｖｏｌ．２２, 1997, ｐｐ．１２８-１３２
JPN6012022031; Ｎａｔｕｒｅ Ｇｅｎｅｔｉｃｓ Ｖｏｌ．３０， Ｎｏ．１, 2002, ｐｐ．７７-８０
JPN6012022034; ＰＮＡＳ Ｖｏｌ．１００， Ｎｏ．１１, 2003, ｐｐ．６３６４-６３６９
JPN6012022036; ＰＮＡＳ Ｖｏｌ．１０１， Ｎｏ．１９, 2004, ｐｐ．７３９８-７４０３
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Gen Tashiro
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Gen Tashiro