Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHODS FOR ISOLATING PROPARGYLATED AMINOINDANES
Document Type and Number:
Japanese Patent JP2014074033
Kind Code:
A
Abstract:

To provide methods for isolating from a reaction mixture a salt of a mono-propargylated aminoindane (rasagiline), which is a selective inhibitor of MAO-B and useful in treating Parkinson's disease etc.

Disclosed are production methods for isolating from a reaction mixture a salt of a mono-propargylated aminoindane having the specified structure. The production methods comprise a) adding an acid to the reaction mixture; b) crystallizing the mono-propargylated aminoindane under conditions suitable for formation of a crystalline salt of the mono-propargylated aminoindane; and c) recovering the crystalline salt of the mono-propargylated aminoindane. Also disclosed are crystalline diastereomeric salts and pharmaceutical compositions containing the salts.


Inventors:
Frenkel, Anton
Lidor-hadas, Ramy
Eduard, Gurevich
Gsan, Attili
Application Number:
JP2013000233575
Publication Date:
April 24, 2014
Filing Date:
November 11, 2013
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
TEVA PHARMACEUTICAL INDUSTRIES LTD
International Classes:
C07C209/88; A61K31/135; A61P25/16; A61P43/00; C07B57/00; C07C211/42
Domestic Patent References:
JPH03294248A1991-12-25
JPH09505806A1997-06-10
JP2000508292A2000-07-04
Attorney, Agent or Firm:
蔵田 昌俊
福原 淑弘
野河 信久
峰 隆司