Title:
適応免疫における免疫調節物質の効果をモニターするための方法およびキット
Document Type and Number:
Japanese Patent JP5892791
Kind Code:
B2
Abstract:
The invention provides for noninvasive assessment of immunocompetence in various situations, for example, when modified by disease or by immunomodulators. The assessment determines the functional activity of germinal centers via measuring levels of immunogolublin isotype class switching. The invention provides for assessment of therapeutic efficacy of immunomodulators and for selection of treatment regimens. The invention also provides for determining the risk or susceptibility to adverse events upon receipt of therapy. Compositions, kits and methods are described herein.
Inventors:
Fedik, Eric Earl.
Application Number:
JP2011509485A
Publication Date:
March 23, 2016
Filing Date:
May 14, 2009
Export Citation:
Assignee:
MILLENNIUM PHARMACEUTICALS, INC.
International Classes:
C12Q1/68; C12M1/00; G01N33/15; G01N33/50; G06F19/20
Domestic Patent References:
| JP2007129960A | ||||
| JP2005312435A | ||||
| JP2005055227A |
Foreign References:
| WO2007032496A1 | ||||
| WO2007020081A1 | ||||
| WO2006081248A2 | ||||
| US20040137539 | ||||
| WO2003031934A2 |
Other References:
PACHUEN POTUP,IMMUNOGLOBULIN CLASS SWITCHING INDUCED BY PLASMODIUM FALCIPARUM IN VITRO,DOCTOR THESIS,MAHIDOL UNIVERSITY,2007年,p.141,http://www.li.mahidol.ac.th/thesis/2550/cd428/4537226.pdf#search=%27human+ct%CE%B3%27
KUNKEL,E.J. AND BUTCHER,E.C.,Plasma-cell homing.,Nat. Rev. Immunol.,2003年10月,Vol.3, No.10,pp.822-9
KUNKEL,E.J. AND BUTCHER,E.C.,Plasma-cell homing.,Nat. Rev. Immunol.,2003年10月,Vol.3, No.10,pp.822-9
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita