Title:
レチノイド受容体によって仲介される過程の修飾方法およびそれに有用な化合物
Document Type and Number:
Japanese Patent JP4001618
Kind Code:
B2
Abstract:
In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid receptors, employing high affinity, high specifity ligands for such receptors. In one aspect of the present invention, there are provided ligands which are more selective for the retinoid X receptor than is retinoic acid (i.e., rexoids). In another aspect of the present invention, alternative ligands (other than retinoic acid) have been discovered which are capable of inducing retinoic acid receptor mediated processes. In yet another aspect, methods have been developed for the preparation of such retinoid receptor ligands from readily available compounds.
Inventors:
Evans, Ronald, M.
Mangersdorf, David Jay.
Hyman, Richard A.
Baume, Marcus F.
Eychel, gregor
Salah, christina
Mangersdorf, David Jay.
Hyman, Richard A.
Baume, Marcus F.
Eychel, gregor
Salah, christina
Application Number:
JP51122193A
Publication Date:
October 31, 2007
Filing Date:
December 18, 1992
Export Citation:
Assignee:
The Saulk Institute For Biological Studies
BAYLOR COLLEGE OF MEDICINE
Ligand Pharmaceuticals, Inc.
BAYLOR COLLEGE OF MEDICINE
Ligand Pharmaceuticals, Inc.
International Classes:
A61K31/20; G01N33/566; A61K31/07; A61K31/19; A61K31/203; A61K31/23; A61K31/232; A61K38/52; A61P3/06; A61P35/00; A61P43/00; C07C57/26; C07C59/46; C07C59/80; C07C403/00; C07C403/20; C07K14/705; C12P7/04; C12P7/62; C12P7/64; C12P9/00
Domestic Patent References:
| JP1156921A | ||||
| JP3141218A | ||||
| JP3118318A | ||||
| JP2288822A |
Other References:
Leuk.Res.,Vol.10,No.6,(1986)p.619-629
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Utamon Shoji
Hajime Asamura
Naganuma Akio
Utamon Shoji