Title:
オルト置換アリールメタル化合物の製造および親電子試薬とのそれらの反応のための方法
Document Type and Number:
Japanese Patent JP4481407
Kind Code:
B2
Abstract:
Catalytic amount of a secondary metal amide is used in the preparation of o-substituted aryl metal compounds (I) by deprotonation of aromatic compounds which possess a hydrogen atom in o-position to e.g. a halogen atom, followed by treatment with an electrophile. The deprotonation of the aromatic compounds is effected using alkyl or aryl metal compounds or metalhydrides. Preparation of o-substituted arylmetal compounds (I) comprises deprotonation of aromatic compounds which possess a hydrogen atom in o-position to at least a halogen atom, a trifluoromethoxy, a dialkylamino, a nitrile, an alkoxy or a dialkylamide group followed by treatment with an electrophile. The deprotonation of the aromatic compounds is conducted using alkyl or aryl metal compounds or metalhydrides in the presence of a catalytic amount of a secondary metal amide.
Inventors:
Hans-Christian Steersney
Volker Reifenrath
Volker Reifenrath
Application Number:
JP35907099A
Publication Date:
June 16, 2010
Filing Date:
December 17, 1999
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C07B37/04; C07C25/13; C07C29/38; C07C33/46; C07C35/50; C07C41/26; C07C43/23; C07F1/00; C07F1/02; C07F5/04; C07F7/08; C07F7/12
Domestic Patent References:
| JP7070140A | ||||
| JP10059980A |
Attorney, Agent or Firm:
Kiyoji Kuzuwa