Title:
Sp35またはTrkAアンタゴニストの投与により髄鞘形成、ニューロンの生存および希乏突起膠細胞の分化を促進するための方法
Document Type and Number:
Japanese Patent JP2009544703
Kind Code:
A
Abstract:
This invention relates to methods for promoting myelination, neuronal survival, and oligodendrocyte differentiation and treating demyelination and dysmyelination disease by the administration of a TrkA antagonist. The invention also relates to methods of inhibiting or decreasing Sp35 expression by the use of a TrkA antagonist. Additionally, the invention relates generally to methods for blocking Sp35 and TrkA interaction and inhibiting or decreasing TrkA phosphorylation by the administration of a Sp35 antagonist.
Inventors:
Me, sha
Jung, Vincent
Jung, Vincent
Application Number:
JP2009521795A
Publication Date:
December 17, 2009
Filing Date:
July 24, 2007
Export Citation:
Assignee:
Biogen Idec MA Inc.
International Classes:
A61K39/395; A61K31/7088; A61K31/713; A61K35/76; A61K47/48; A61K48/00; A61P3/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P43/00; C07K14/47; C07K14/705; C12N15/09
Domestic Patent References:
| JP2000501416A | 2000-02-08 | |||
| JP2000514420A | 2000-10-31 | |||
| JPH09502730A | 1997-03-18 |
Foreign References:
| WO1999048908A2 | 1999-09-30 |
Other References:
JPN6012051797; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｌｏｇｉｃａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２７７， Ｎｏ．５１, 2002, ｐ．４９４７３-４９４８０
JPN6012051800; Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｒｅｓｅａｒｃｈ Ｖｏｌ．７９, 2005, ｐ．３１０-３１７
JPN6012051802; Ｎｅｕｒｏｎ Ｖｏｌ．４３， Ｎｏ．２, 2004, ｐ．１８３-１９１
JPN6012051800; Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｒｅｓｅａｒｃｈ Ｖｏｌ．７９, 2005, ｐ．３１０-３１７
JPN6012051802; Ｎｅｕｒｏｎ Ｖｏｌ．４３， Ｎｏ．２, 2004, ｐ．１８３-１９１
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita