Title:
オリゴヌクレオチドの合成および精製に使用する方法および反応試薬
Document Type and Number:
Japanese Patent JP2007531794
Kind Code:
A
Abstract:
The present invention relates to a method of removing a silyl protecting group from an oligonucleotide, said method comprising the step of admixing the oligonucleotide with particular agents.
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Inventors:
Manoharan, Musia
Jung, Michael Yee
Rajiv, Karan Sotasil Gee
Panday, Rajendra
One, gun
Jung, Michael Yee
Rajiv, Karan Sotasil Gee
Panday, Rajendra
One, gun
Application Number:
JP2007507431A
Publication Date:
November 08, 2007
Filing Date:
April 05, 2005
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS, INC.
International Classes:
C07H21/00; C07C327/22; C07D207/32; C07D213/55; C07D231/56; C07D233/90; C07D249/14; C07D249/18; C07D257/04; C07D257/06; C07D285/00; C07D285/01; C07D339/08; C07D471/04; C07F9/655; C07H19/10; C07H21/02; C07H21/04; C12P1/00; C07B61/00
Domestic Patent References:
| JPH1072448A | 1998-03-17 | |||
| JP2004099532A | 2004-04-02 | |||
| JPH09211808A | 1997-08-15 | |||
| JPS5989673A | 1984-05-23 | |||
| JP2004031443A | 2004-01-29 |
Foreign References:
| WO2002059093A1 | 2002-08-01 | |||
| WO2001010880A1 | 2001-02-15 | |||
| US4474948A | 1984-10-02 | |||
| US3732239A | 1973-05-08 | |||
| US3740396A | 1973-06-19 | |||
| US4240822A | 1980-12-23 | |||
| DE3406011A1 | 1985-08-22 | |||
| GB2011391A | 1979-07-11 | |||
| GB1242955A | 1971-08-18 |
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma