Title:
患者から胆汁酸塩を除去する方法およびそのためのアルキル化組成物
Document Type and Number:
Japanese Patent JP3931217
Kind Code:
B2
Abstract:
A method for removing bile salts from a patient that includes administering to the patient a therapeutically effective amount of the reaction product of: (a) one or more highly cross-linked polymers characterized by a repeat unit selected from the group consisting essentially of: (1), (2), (3): (NR-CH2 -CH2)n, (4): (NR-CH2CH2-NR-CH2CH2-NR-CH2CHOH-CH2)n and salts and copolymers thereof, where n is an integer and each r, independently, is H or a C1-C8 alkyl group; and (b) at least one alkylating agent. The reaction product is characterised in that: (i) at least some of the nitrogen atoms in said repeat units are unreacted with said alkylating agent; (ii) less than 10 mol% of the nitrogen atoms in the repeat units that react with the alkylating agent from quaternary ammonium units; and (iii) the reaction product is non-toxic and stable once ingested.
Inventors:
Mandeville, W. Harry, The Third.
Holmes-Farley, Stephen Rundle
Holmes-Farley, Stephen Rundle
Application Number:
JP50230696A
Publication Date:
June 13, 2007
Filing Date:
June 05, 1995
Export Citation:
Assignee:
Genzyme Corporation
International Classes:
C08F8/44; A01N33/18; A61K31/04; A61K31/785; A61K31/787; A61P1/16; A61P3/06; C08F8/00; C08F8/02; C08F16/00; C08F18/22; C08F26/02; C08F116/00; C08F220/34; C08F220/60; C08F283/00; C08G69/26; C08G73/00; C08G73/02; C08G81/00; A61K
Domestic Patent References:
| JP7309766A | ||||
| JP2232229A | ||||
| JP49111998A | ||||
| JP5505851A | ||||
| JP55066513A | ||||
| JP6166728A | ||||
| JP7157671A |
Attorney, Agent or Firm:
Yoshinori Hosoda
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