Title:
SELECTIVE EXPANSION METHOD OF DIFFERENT SUBPOPULATION OF T CELL BY ALTERATION OF CELL SURFACING SIGNAL AND SIGNAL RATIO
Document Type and Number:
Japanese Patent JP2022119956
Kind Code:
A
Abstract:
To provide compositions and methods for specific expansion of subpopulations of specific T cell subtypes from the general T cell population.SOLUTION: A method for selectively expanding members of a T cell subpopulation includes exposing a mixed population of T cells to: (a) a first agent which provides a primary activation signal to the members of the T cell subpopulation, thereby activating the T cells, and (b) a second agent and a third agent, each of which stimulates two or more different accessory molecules on the members of the T cell subpopulation, thereby stimulating the proliferation of the activated T cells of (a), the ratios of the first agent, the second agent, and the third agent being adjusted to induce the members of the T cell subpopulation to selectively expand over members of other T cell subpopulations.SELECTED DRAWING: Figure 1A
Inventors:
HILDE KJERSTI ALMAASBAK
TANJA AARVAK
KERSTIN BERNSTROEM
OYSTEIN AAMELLEM
TANJA AARVAK
KERSTIN BERNSTROEM
OYSTEIN AAMELLEM
Application Number:
JP2022090011A
Publication Date:
August 17, 2022
Filing Date:
June 02, 2022
Export Citation:
Assignee:
LIFE TECH AS
International Classes:
C12N5/0783; A61K35/17; A61P1/04; A61P3/10; A61P17/00; A61P19/02; A61P27/02; A61P29/00; A61P29/02; A61P31/00; A61P35/00; A61P37/06; A61P37/08; C07K14/725; C07K16/00; C07K19/00; C12N1/00; C12N5/10; C12N15/12; C12N15/13; C12N15/19; C12N15/24; C12N15/25; C12N15/26; C12N15/62
Domestic Patent References:
| JP2002531376A | 2002-09-24 |
Other References:
KALAMASZ D. ET AL., J IMMUNOTHER, vol. 27, JPN6023027222, 2004, pages 405 - 18, ISSN: 0005100580
TESCHNER D. ET AL., SCAND J IMMUNOL, vol. 74, JPN6023027221, 2011, pages 155 - 64, ISSN: 0005100581
LI Y. ET AL., J TRANSL MED, vol. Vol. 8:104, JPN6023027220, 2010, ISSN: 0005100582
TESCHNER D. ET AL., SCAND J IMMUNOL, vol. 74, JPN6023027221, 2011, pages 155 - 64, ISSN: 0005100581
LI Y. ET AL., J TRANSL MED, vol. Vol. 8:104, JPN6023027220, 2010, ISSN: 0005100582
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto