Title:
ミスフォールドタンパク質エピトープを予測するための方法およびシステム
Document Type and Number:
Japanese Patent JP5898495
Kind Code:
B2
Abstract:
A method and system to identify an epitope unique to a misfolded form of a protein is provided. Sets of one or more amino acid residues are selected from a model representing the structure of the protein; the free energy of unfolding of each set is determined; and the epitope is identified from the sets having a total probability of unfolding above a minimum probability or a free energy of unfolding below a minimum energy. In other aspects, the invention provides for the use of epitopes identified by the epitope prediction methods, and related antibodies, to diagnose and treat disease and to screen samples for the presence of such epitopes.
Inventors:
Cashman, Neil Earl.
Plotkin, Stephen S.
Guest, William Sea.
Plotkin, Stephen S.
Guest, William Sea.
Application Number:
JP2011529431A
Publication Date:
April 06, 2016
Filing Date:
October 06, 2009
Export Citation:
Assignee:
The University of British Columbia
International Classes:
G16B5/30; A61K39/395; A61P11/00; A61P13/12; A61P15/00; A61P17/00; A61P25/00; A61P31/00; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07K14/47; C07K16/00; C12P21/08; G16B15/20; G16B20/30; G16B20/50
Domestic Patent References:
| JP2007502966A | ||||
| JP2003521477A |
Foreign References:
| WO2004113387A2 | ||||
| WO2001097827A1 |
Other References:
Victor Munoz, William A. Eaton,A simple model for calculating the kinetics of protein folding from three-dimensional structures,Proc. Natl. Acad. Sci.,1999年 9月,Vol.96 No.20,pp.11311-11316
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita