Title:
ボロン酸およびその中間体を生成させるための方法およびシステム
Document Type and Number:
Japanese Patent JP6425543
Kind Code:
B2
Abstract:
Methods for forming boronic acids, and intermediates thereof, are disclosed. The method may include mixing a 1-chloro-2-substituted-3-fluorobenzene starting material with an alkyllithium in a first reactor to form a reaction mixture. The 1-chloro-2-substituted-3-fluorobenzene starting material may react with the alkyllithium to form a lithiated intermediate. The reaction mixture may be continuously transferred to a second reactor and a borate may be continuously introduced to form a boronate. The boronic acids may be formed by treating the boronate with aqueous potassium hydroxide followed by acidification. Such methods may provide continuous formation of the boronic acids and may reduce an amount of a reactive intermediate present during processing as well as cycle times. Systems for forming the boronic acids are also disclosed.
Inventors:
Menning, Catherine, A.
Bray Rock, Dee., Wayne
Emmons, Mark, Buoy. M.
Bray Rock, Dee., Wayne
Emmons, Mark, Buoy. M.
Application Number:
JP2014530900A
Publication Date:
November 21, 2018
Filing Date:
September 14, 2012
Export Citation:
Assignee:
Dow Agro Sciences LLC
International Classes:
C07F5/02
Domestic Patent References:
| JP2011509300A | ||||
| JP2010538013A | ||||
| JP2000229981A | ||||
| JP2003113185A | ||||
| JP201795472A |
Foreign References:
| WO2010073714A1 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Nao Fujita
Yoshimitsu Maki
Yasuhito Suzuki
Norio Omori
Nao Fujita
Yoshimitsu Maki
Yasuhito Suzuki