Title:
片頭痛および他の適応症の処置のための方法およびシステム
Document Type and Number:
Japanese Patent JP2014501285
Kind Code:
A
Abstract:
The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ergopeptines, triptans, and other compounds, including salts and derivatives of these, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.
Inventors:
Fossel, Eric Tee.
Application Number:
JP2013547685A
Publication Date:
January 20, 2014
Filing Date:
December 29, 2011
Export Citation:
Assignee:
Strategic Science and Technologies, LRC
International Classes:
A61K31/48; A61K9/06; A61K9/08; A61K9/107; A61K9/127; A61K9/70; A61K31/403; A61K31/404; A61K31/4045; A61K31/4196; A61K31/422; A61K31/454; A61K31/506; A61K47/02; A61K47/06; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/22; A61K47/36; A61K47/42; A61P25/06
Domestic Patent References:
| JP2007532696A | 2007-11-15 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita