Title:
心血管状態の薬理ゲノミクス治療のための方法およびシステム
Document Type and Number:
Japanese Patent JP2013508329
Kind Code:
A
Abstract:
Methods and systems are provided herein that are based on the effects of genetic variations on the biological activities associated to rostafuroxin in an individual. In particular, compositions, methods and systems are herein described that are based on an indentified influence on an individual response to rostafuroxin of one or more polymorphisms in an intergenic or intragenic region of a gene selected from the group consisting of KCNS3, THSD7A, FAM46A, LOC389970, HLA-G, and TTC29, and/or a genetic variation in linkage disequilibrium therewith.
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Inventors:
Giuseppe Bianchi
Patrizia Ferrari
Fabio Machiardi
Patrizia Ferrari
Fabio Machiardi
Application Number:
JP2012534642A
Publication Date:
March 07, 2013
Filing Date:
October 18, 2010
Export Citation:
Assignee:
ROSTAQUO S.p.A.
International Classes:
A61K31/56; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P9/14; A61P13/02; A61P25/18; A61P25/28; C12M1/34; C12N15/09; C12Q1/68; G01N33/53
Domestic Patent References:
| JP2005503152A | 2005-02-03 |
Foreign References:
| WO2007060206A2 | 2007-05-31 | |||
| WO2010108855A1 | 2010-09-30 |
Other References:
JPN6012055067; ＷＡＴＡＮＡＢＥ，Ｙ．，ＥＴ ＡＬ．: '"Ａｃｃｕｍｕｌａｔｉｏｎ ｏｆ ｃｏｍｍｏｎ ｐｏｌｙｍｏｒｐｈｉｓｍｓ ｉｓ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｈｙｐｅｒｔｅｎｓｉｏｎ： ａ １２-ｙｅａｒ ｆｏｌｌ' ＨＹＰＥＲＴＥＮＳＩＯＮ ＲＥＳＥＡＲＣＨ． ＣＬＩＮＩＣＡＬ ＡＮＤ ＥＸＰＥＲＩＭＥＮＴＡＬ ＶＯＬ．３３，ＮＯ．２, 20091120, ＰＰ．１２９-１３４
JPN6012055063; ＦＥＲＲＡＲＩ，Ｐ．，ＥＴ ＡＬ．: '"Ｒｏｓｔａｆｕｒｏｘｉｎ： ａｎ ｏｕａｂａｉｎ ａｎｔａｇｏｎｉｓｔ ｔｈａｔ ｃｏｒｒｅｃｔｓ ｒｅｎａｌ ａｎｄ ｖａｓｃｕｌａｒ Ｎａ＋-Ｋ＋-ＡＴＰａｓｅ ａｌｔｅｒａｔｉｏｎｓ ｉｎ ｏ' ＡＭＥＲＩＣＡＮ ＪＯＵＲＮＡＬ ＯＦ ＰＨＹＳＩＯＬＯＧＹ： ＲＥＧＵＬＡＴＯＲＹ， ＩＮＴＥＧＲＡＴＩＶＥ ＡＮＤ ＣＯＭＰＡＲＡＴＩＶＥ ＰＨＹＳＩＯＬＯＧＹ ＶＯＬ．２９０，ＮＯ．３, 2006, ＰＰ．Ｒ５２９-Ｒ５３５
JPN6012055064; ＳＴＡＥＳＳＥＮ，Ｊ． Ａ．，ＥＴ ＡＬ．: '"Ｏｕａｂａｉｎ ａｎｄ Ａｄｄｕｃｉｎ ｆｏｒ Ｓｐｅｃｉｆｉｃ Ｉｎｔｅｒｖｅｎｔｉｏｎ ｏｎ Ｓｏｄｉｕｍ ｉｎ ＨｙｐｅｒＴｅｎｓｉｏｎ （ＯＡＳＩＳ-ＨＴ）： ｄｅｓｉｇｎ ｏｆ ａ ｐｈａ' ＰＨＡＲＭＡＣＯＧＥＮＯＭＩＣＳ ＶＯＬ．６，ＮＯ．７, 2005, ＰＰ．７５５-７７５
JPN6012055065; ＭＡＮＵＮＴＡ，Ｐ．，ＥＴ ＡＬ．: 'Ａｄｄｕｃｉｎ ｐｏｌｙｍｏｒｐｈｉｓｍｓ ａｎｄ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｈｙｐｅｒｔｅｎｓｉｏｎ"' ＰＨＡＲＭＡＣＯＧＥＮＯＭＩＣＳ ＶＯＬ．８，ＮＯ．５, 2007, ＰＰ．４６５-４７２
JPN6012055066; ＦＥＲＲＡＮＤＩ，Ｍ．，ＥＴ ＡＬ．: '"Ｏｕａｂａｉｎ-ｄｅｐｅｎｄｅｎｔ ｓｉｇｎａｌｉｎｇ ｉｎ ｃａｖｅｏｌａｅ ａｓ ａ ｎｏｖｅｌ ｔｈｅｒａｐｅｕｔｉｃ ｔａｒｇｅｔ ｆｏｒ ｈｙｐｅｒｔｅｎｓｉｏｎ"' ＣＥＬＬＵＬＡＲ ＡＮＤ ＭＯＬＥＣＵＬＡＲ ＢＩＯＬＯＧＹ （ＮＯＩＳＹ-ＬＥ-ＧＲＡＮＤ） ＶＯＬ．５２，ＮＯ．８, 2006, ＰＰ．１５-１８
JPN6013046183; ＤＡＴＡＢＡＳＥ ＮＣＢＩ ［Ｏｎｌｉｎｅ］ , 20130910
JPN6012055063; ＦＥＲＲＡＲＩ，Ｐ．，ＥＴ ＡＬ．: '"Ｒｏｓｔａｆｕｒｏｘｉｎ： ａｎ ｏｕａｂａｉｎ ａｎｔａｇｏｎｉｓｔ ｔｈａｔ ｃｏｒｒｅｃｔｓ ｒｅｎａｌ ａｎｄ ｖａｓｃｕｌａｒ Ｎａ＋-Ｋ＋-ＡＴＰａｓｅ ａｌｔｅｒａｔｉｏｎｓ ｉｎ ｏ' ＡＭＥＲＩＣＡＮ ＪＯＵＲＮＡＬ ＯＦ ＰＨＹＳＩＯＬＯＧＹ： ＲＥＧＵＬＡＴＯＲＹ， ＩＮＴＥＧＲＡＴＩＶＥ ＡＮＤ ＣＯＭＰＡＲＡＴＩＶＥ ＰＨＹＳＩＯＬＯＧＹ ＶＯＬ．２９０，ＮＯ．３, 2006, ＰＰ．Ｒ５２９-Ｒ５３５
JPN6012055064; ＳＴＡＥＳＳＥＮ，Ｊ． Ａ．，ＥＴ ＡＬ．: '"Ｏｕａｂａｉｎ ａｎｄ Ａｄｄｕｃｉｎ ｆｏｒ Ｓｐｅｃｉｆｉｃ Ｉｎｔｅｒｖｅｎｔｉｏｎ ｏｎ Ｓｏｄｉｕｍ ｉｎ ＨｙｐｅｒＴｅｎｓｉｏｎ （ＯＡＳＩＳ-ＨＴ）： ｄｅｓｉｇｎ ｏｆ ａ ｐｈａ' ＰＨＡＲＭＡＣＯＧＥＮＯＭＩＣＳ ＶＯＬ．６，ＮＯ．７, 2005, ＰＰ．７５５-７７５
JPN6012055065; ＭＡＮＵＮＴＡ，Ｐ．，ＥＴ ＡＬ．: 'Ａｄｄｕｃｉｎ ｐｏｌｙｍｏｒｐｈｉｓｍｓ ａｎｄ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｈｙｐｅｒｔｅｎｓｉｏｎ"' ＰＨＡＲＭＡＣＯＧＥＮＯＭＩＣＳ ＶＯＬ．８，ＮＯ．５, 2007, ＰＰ．４６５-４７２
JPN6012055066; ＦＥＲＲＡＮＤＩ，Ｍ．，ＥＴ ＡＬ．: '"Ｏｕａｂａｉｎ-ｄｅｐｅｎｄｅｎｔ ｓｉｇｎａｌｉｎｇ ｉｎ ｃａｖｅｏｌａｅ ａｓ ａ ｎｏｖｅｌ ｔｈｅｒａｐｅｕｔｉｃ ｔａｒｇｅｔ ｆｏｒ ｈｙｐｅｒｔｅｎｓｉｏｎ"' ＣＥＬＬＵＬＡＲ ＡＮＤ ＭＯＬＥＣＵＬＡＲ ＢＩＯＬＯＧＹ （ＮＯＩＳＹ-ＬＥ-ＧＲＡＮＤ） ＶＯＬ．５２，ＮＯ．８, 2006, ＰＰ．１５-１８
JPN6013046183; ＤＡＴＡＢＡＳＥ ＮＣＢＩ ［Ｏｎｌｉｎｅ］ , 20130910
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Manami Sawamoto
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Manami Sawamoto