Title:
異常な細胞増殖を治療するための方法
Document Type and Number:
Japanese Patent JP2008501007
Kind Code:
A
Abstract:
Therapeutic pharmaceutical compositions and methods of treatment of abnormal cell growth comprising a pyrimidine derivative or a pharmaceutically acceptable salt, solvate or prodrug thereof in combination with an oral camptothecin, an oral camptothecin derivative, an indolopyrrocarbazole derivative or a pharmaceutically acceptable salt, solvate or prodrug thereof for the treatment of cancer are described. In one embodiment of the present invention the oral camptothecin derivative is selected from the group consisting of 10-hydroxycamptothecin, 9-aminocamptothecin, 9-nitrocamptothecin, irinotecan, irinotecan salt, SN-38, CPT-11, and topotecan and the indolopyrrocarbazole derivative is edotecarin. In one embodiment the pyrimidine derivative is selected from the group consisting gemcitabine, MTA and capecitabine. In one preferred embodiment, the pyrimidine derivative is capecitabine and the camptothecin derivative is CPT-11.
Inventors:
Miller, Langdon-les-Forest
Denis, Louis Jean
Linda Darren, Compton
Denis, Louis Jean
Linda Darren, Compton
Application Number:
JP2007514172A
Publication Date:
January 17, 2008
Filing Date:
May 17, 2005
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
A61K31/513; A61K31/407; A61K31/4745; A61K31/7056; A61K31/7068; A61P35/00
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho