METHODS FOR TREATING FATTY LIVER DISEASE

Title:

METHODS FOR TREATING FATTY LIVER DISEASE

Document Type and Number:

Japanese Patent JP2020114884

Kind Code:

A

Abstract:

To provide agents that function as potent regulators of signaling by members of TGF-β superfamily for treating fatty liver disease.SOLUTION: In certain aspects, the present invention provides compositions and methods for treating fatty liver disease by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies and anti-activin A or B antibodies. A variety of hepatic and metabolic disorders may be improved by treating fatty liver disease.SELECTED DRAWING: None

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Inventors:

ALAN KONCAREVIC
JENNIFER LACHEY
JASBIR SEEHRA
SHERMAN MATTHEW L

Application Number:

JP2020081121A

Publication Date:

July 30, 2020

Filing Date:

May 01, 2020

Export Citation:

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Assignee:

ACCELERON PHARMA INC

International Classes:

A61K38/17; A61K39/395; A61K47/68; A61P1/16; A61P3/00; A61P3/06; A61P3/08; A61P3/10

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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