Title:
タンパク質凝集疾患を治療するための方法
Document Type and Number:
Japanese Patent JP2007521255
Kind Code:
A
Abstract:
The present invention is based, at least in part on the discovery of therapeutic agents capable of preventing, inhibiting or modulating abnormal processing, misfolding or aggregation of protein. The therapeutic agents of the invention may prevent, inhibit or modulate the formation of inclusions. The therapeutic agents of the invention may also be capable of facilitating clearance and/or blocking the cellular toxicity of inclusions to treat or ameliorate disorders characterized by protein aggregation. Compounds which bind to structural motifs commonly found in protein aggregates, such as ß-sheets, would represent strong candidates for such compounds and are therefore desirable.
Inventors:
Trenbrae Patrick
McCrawlin Richard
McCrawlin Richard
Application Number:
JP2006516603A
Publication Date:
August 02, 2007
Filing Date:
June 21, 2004
Export Citation:
Assignee:
Neurochem (International) Limited
International Classes:
A61K31/185; A61K31/18; A61K31/198; A61K31/222; A61K31/223; A61K31/255; A61K31/27; A61K31/277; A61K31/325; A61K31/343; A61K31/36; A61K31/381; A61K31/39; A61K31/40; A61K31/401; A61K31/4035; A61K31/4045; A61K31/405; A61K31/41; A61K31/4152; A61K31/4164; A61K31/417; A61K31/421; A61K31/426; A61K31/428; A61K31/435; A61K31/4355; A61K31/4365; A61K31/439; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/4425; A61K31/4436; A61K31/4439; A61K31/445; A61K31/4453; A61K31/451; A61K31/455; A61K31/47; A61K31/472; A61K31/473; A61K31/495; A61K31/505; A61K31/535; A61K31/5375; A61K31/54; A61K31/55; A61K31/655; A61K31/661; A61K31/662; A61K31/70; A61K31/7008; A61K31/7016; A61K31/7024; A61K38/00; A61P1/16; A61P7/06; A61P9/02; A61P9/10; A61P11/00; A61P19/00; A61P21/00; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/12; C07D231/48; C07D495/04; C07D207/08; C07D207/16; C07D207/325; C07D209/14; C07D209/20; C07D209/46; C07D209/48; C07D211/14; C07D211/58; C07D211/64; C07D211/70; C07D211/82; C07D213/20; C07D213/36; C07D213/74; C07D213/82; C07D215/26; C07D217/04; C07D217/26; C07D219/10; C07D221/16; C07D223/12; C07D233/26; C07D233/60; C07D239/06; C07D257/04; C07D263/10; C07D263/16; C07D265/08; C07D275/06; C07D277/10; C07D277/12; C07D279/06; C07D295/08; C07D307/81; C07D317/58; C07D319/06; C07D327/04; C07D327/06; C07D333/20; C07D333/48; C07D333/58; C07D401/04; C07D409/04; C07D411/12; C07D453/06; C07D471/04; C07H3/04; C07H5/10; C07H11/00; C07H15/12
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi