Title:
2α-メチル-19-ノル-(20S)-1α-ヒドロキシ-ビスホモプレグナカルシフェロールおよびその使用
Document Type and Number:
Japanese Patent JP2008520703
Kind Code:
A
Abstract:
This invention discloses 2α-methyl-19-nor-(20S)-vitamin D analogs, and specifically 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
Inventors:
Deluca, Hector Ef
Rafal Earl
Plum, Lori Ai
Claget-Darm, Margaret
Rafal Earl
Plum, Lori Ai
Claget-Darm, Margaret
Application Number:
JP2007543267A
Publication Date:
June 19, 2008
Filing Date:
November 18, 2005
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
C07C35/21; A61K31/59; A61P1/04; A61P3/04; A61P3/10; A61P5/18; A61P9/12; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P17/10; A61P17/14; A61P17/16; A61P19/00; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61K8/67; A61Q19/00; A61Q19/08; C07F7/08
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri