Title:
MICRO-MOLDED OR THREE-DIMENSIONALLY PRINTED PULSE-RELEASING VACCINE PREPARATION
Document Type and Number:
Japanese Patent JP2021120413
Kind Code:
A
Abstract:
To provide an emulsion-based and micro-molded ("MM"), or three-dimensionally printed ("3DP") polymer preparation for single injection of antigen that is released preferably in two or more periods of time.SOLUTION: A preparation is preferably formed of biocompatible and biodegradable polymer. Separate regions for encapsulating antigen exist in the preparation alone or in combination with other antigen, adjuvant, stabilizer and release regulator. The antigen exists preferably in a filler at the time of administration or exists on the surface of the preparation for immediate release, then, incorporated into the preparation in order to be released in 10 to 45 days after the initial release of antigen, and for release of antigen at the interval of 10 to 90 days in one or more periods of time as needed.SELECTED DRAWING: None
Inventors:
ANA JAKLENEC
WILLIAM GATES
PHILIP A ECKHOFF
BORIS NIKOLIC
LOWELL L WOOD JR
ROBERT S LANGER
THANH DUC NGUYEN
STEPHANY YI TZENG
JAMES J NORMAN
KEVIN MCHUGH
WILLIAM GATES
PHILIP A ECKHOFF
BORIS NIKOLIC
LOWELL L WOOD JR
ROBERT S LANGER
THANH DUC NGUYEN
STEPHANY YI TZENG
JAMES J NORMAN
KEVIN MCHUGH
Application Number:
JP2021085890A
Publication Date:
August 19, 2021
Filing Date:
May 21, 2021
Export Citation:
Assignee:
MASSACHUSETTS INST TECHNOLOGY
TOKITAE LLC
TOKITAE LLC
International Classes:
A61K9/16; A61K9/50; A61K39/00; A61K39/02; A61K39/05; A61K39/08; A61K39/09; A61K39/10; A61K39/12; A61K39/13; A61K39/145; A61K39/15; A61K39/165; A61K39/20; A61K39/25; A61K39/29; A61K47/02; A61K47/12; A61K47/26; A61K47/34; A61K47/44; A61L27/02; A61L27/18; A61L27/40; A61L27/54; A61L27/58; A61P1/16; A61P31/00; A61P31/10; A61P31/12; A61P31/16; A61P33/02; A61P35/00; A61P37/04; B29C64/106; B29C64/112; B33Y10/00; B33Y70/00
Domestic Patent References:
| JPH09504027A | 1997-04-22 | |||
| JP2011514337A | 2011-05-06 |
Other References:
ADVANCED DRUG DELIVERY REVIEWS, vol. 65, JPN6019027399, 13 July 2013 (2013-07-13), pages 1611 - 1625, ISSN: 0005047928
INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 339, JPN6023017776, 2007, pages 33 - 38, ISSN: 0005047929
INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 339, JPN6023017776, 2007, pages 33 - 38, ISSN: 0005047929
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita