Title:
MICROFLUIDIZED OIL-IN-WATER EMULSION AND VACCINE COMPOSITION
Document Type and Number:
Japanese Patent JP2011168605
Kind Code:
A
Abstract:
To provide submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens.
In the submicron oil-in-water emulsions, the antigen is a viral antigen, a bacterial antigen, or a combination thereof, the adjuvant is Quil A, cholesterol, GPI-0100, dimethyldioctadecylammonium bromide, etc. Vaccine compositions contain the antigen combined with the emulsion intrinsically or extrinsically. Furthermore, a method for making the emulsion and vaccine is provided.
Inventors:
Dominowski, Paul Joseph
Klose, Pamela Kay
Krebs, Richard Lee
Mannan, Ramasamy Mannar
Klose, Pamela Kay
Krebs, Richard Lee
Mannan, Ramasamy Mannar
Application Number:
JP2011000089018
Publication Date:
September 01, 2011
Filing Date:
April 13, 2011
Export Citation:
Assignee:
PFIZER PRODUCTS INC
International Classes:
A61K39/12; A61K9/107; A61K39/02; A61K39/09; A61K39/155; A61K39/245; A61K39/39; A61K47/10; A61K47/28; A61P31/04; A61P31/12; A61P31/14
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