Title:
MICROPARTICLE HAVING ADSORBED POLYPEPTIDE-CONTAINING MOLECULE
Document Type and Number:
Japanese Patent JP2016006109
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide microparticles having adsorbed polypeptide-containing molecules formed without the use of a surfactant, and to provide a method for making such microparticle compositions.SOLUTION: Microparticles comprise polymers (for example, poly (α-hydroxy acid), polyhydroxy butyric acid, polycaprolactone, polyorthoester, polyanhydride and polycyanoacrylate, and the like. Polymers are preferably poly(D, L-lactide-co-glycolides), and more preferably poly(D, L-lactide-co-glycolides) having a lactide/glycolide molar ratio ranging from 40:60 to 60:40 and having a molecular weight ranging from 20,000 Daltons to 70,000 Daltons. Preferred polypeptide-containing molecules are bacterial antigens and viral antigens.
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Inventors:
O'HAGAN DEREK
SINGH MANMOHAN
KAZZAZ JINA
SINGH MANMOHAN
KAZZAZ JINA
Application Number:
JP2015162589A
Publication Date:
January 14, 2016
Filing Date:
August 20, 2015
Export Citation:
Assignee:
NOVARTIS VACCINES & DIAGNOSTIC
International Classes:
A61K9/16; A61K9/14; A61K31/713; A61K38/00; A61K38/22; A61K38/43; A61K39/00; A61K39/02; A61K39/05; A61K39/08; A61K39/09; A61K39/095; A61K39/10; A61K39/102; A61K39/12; A61K39/145; A61K39/21; A61K39/29; A61K39/39; A61K45/00; A61K47/34; A61K47/48; A61K48/00; A61P31/04; A61P31/16; A61P31/18; A61K9/00
Domestic Patent References:
| JPH06340550A | 1994-12-13 | |||
| JPH11508912A | 1999-08-03 | |||
| JPH08505836A | 1996-06-25 | |||
| JP2001511148A | 2001-08-07 |
Other References:
JPN6009043613; ＣＡＲＲＩＯ Ａ． ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｃｏｎｔｒｏｌｌｅｄ Ｒｅｌｅａｓｅ Ｖｏｌ．３７, 1995, ｐ．１１３-１２１
JPN6009043614; ＪＥＯＮＧ Ｙ． ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ａｐｐｌｉｅｄ Ｐｏｌｙｍｅｒ Ｓｃｉｅｎｃｅ Ｖｏｌ．８０, 2001, ｐ．２２２８-２２３６
JPN6009043614; ＪＥＯＮＧ Ｙ． ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ａｐｐｌｉｅｄ Ｐｏｌｙｍｅｒ Ｓｃｉｅｎｃｅ Ｖｏｌ．８０, 2001, ｐ．２２２８-２２３６
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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