MICROSPHERE FOR ACTIVE EMBOLIZATION

Japanese Patent JP2013082743

A

To provide injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy.

Substantially spherical microspheres suitable for active embolization includes (a) biocompatible and hydrophobic polymers including vinyl alcohol polymers, poly(lactic acid), polyacrylamides, poly(anhydrides), polysaccharides, silicones, or mixtures thereof, and (b) antineoplastic agents. Furthermore, embolization gene therapy for the treatment of especially neovascular and angiogenesis-dependent diseases uses the injectable compositions.

VOGEL JEAN-MARIE
BOSCHETTI EGISTO

JP2013006883A

May 09, 2013

January 18, 2013

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BIOSPHERE MEDICAL INC

A61K9/14; A61K9/00; A61K9/10; A61K9/107; A61K9/16; A61K31/138; A61K31/255; A61K31/337; A61K31/395; A61K31/407; A61K31/475; A61K31/704; A61K31/7084; A61K31/715; A61K33/24; A61K38/00; A61K39/00; A61K39/02; A61K39/04; A61K39/05; A61K39/08; A61K39/09; A61K39/095; A61K39/10; A61K39/106; A61K39/112; A61K39/12; A61K39/125; A61K39/13; A61K39/145; A61K39/155; A61K39/20; A61K39/205; A61K39/21; A61K39/25; A61K39/29; A61K45/00; A61K45/06; A61K47/02; A61K47/04; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K49/00; A61K49/04; A61P9/00; A61P9/10; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P27/02; A61P29/00; A61P35/00

JP2008214355A	2008-09-18
JPH05969A	1993-01-08
JPH0656676A	1994-03-01
JPH06508139A	1994-09-14
JPH09505059A	1997-05-20
JPH09503488A	1997-04-08
JPH05969A	1993-01-08
JPH05294839A	1993-11-09
JPH06508139A	1994-09-14

CA2248592A1	2000-02-29
CA2248592A1	2000-02-29

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Nobuko Fukami

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