Title:
MICROVESICLE AND STEM CELL COMPOSITIONS FOR THERAPEUTIC APPLICATIONS
Document Type and Number:
Japanese Patent JP2023145686
Kind Code:
A
Abstract:
To provide stem cells and exosome compositions having therapeutic utility to treat a variety of diseases and disorders, e.g., cardiovascular disease, Duchenne muscular dystrophy, and fibrotic disease.SOLUTION: The invention provides an exosome or microvesicle selected from among an iPSC cell, an embryonic stem cell, and a stem cell that has been contacted with an effective amount of an isoxazole compound, a derivative or equivalent thereof, or Danazol, where the exosome or microvesicle overexpresses one or more of: a) a microRNA (miRNA) selected from among mir-373, mir-210, mir-377, mir-367, mir-520, mir-548ah, mir-335, mir-21, mir-30c, mir-214 and mir-548q; and/or b) one or more proteins selected from among Tsg101, CD9, Hsp70, Flotillin-1 and GAPDH.SELECTED DRAWING: None
Inventors:
MUHAMMAD ASHRAF
Application Number:
JP2023126654A
Publication Date:
October 11, 2023
Filing Date:
August 03, 2023
Export Citation:
Assignee:
MUHAMMAD ASHRAF
International Classes:
C12N5/10; A61K31/42; A61K35/545; A61P9/00; A61P19/00; A61P21/00; A61P43/00
Attorney, Agent or Firm:
Patent Attorney Corporation Suma Patent Office