Title:
鉱質コルチコイド受容体アンタゴニスト
Document Type and Number:
Japanese Patent JP2010522732
Kind Code:
A
Abstract:
Compounds of the formula (I) are provided having a steroid skeleton and substitution characteristics in the A and B rings of the steroid skeleton effective for mineralocorticoid receptor antagonism, and rings C and D of the steroid skeleton having substituents thereon according to formula (I), wherein R1 is —OH or ═O; R2 is (C1-3)alkyl or (C2-3)alkenyl; R3 is selected from formulas (IIa), (IIb), (IIc). These compounds are useful in the treatment of inter alia aldosteronism, hypokalemia, hypertension, congestive heart failure, heart fibrosis, renal failure and restenosis.
Inventors:
Peters, Bernardos Winand Matthews Marie
Flune, Marinas Bernard
Plate, ralph
Flune, Marinas Bernard
Plate, ralph
Application Number:
JP2010500340A
Publication Date:
July 08, 2010
Filing Date:
March 29, 2007
Export Citation:
Assignee:
Narmrose Fuennault Chap Organon
International Classes:
C07J7/00; A61K31/57; A61K31/575; A61P1/16; A61P3/04; A61P3/10; A61P3/12; A61P5/28; A61P7/10; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P15/00; A61P25/00; A61P27/02; A61P43/00; C07J9/00; C07J31/00; C07J53/00
Domestic Patent References:
| JPS577498A | 1982-01-14 | |||
| JPS577498A | 1982-01-14 |
Foreign References:
| GB1214507A | 1970-12-02 | |||
| GB1292716A | 1972-10-11 | |||
| DE2839033A1 | 1980-03-13 | |||
| GB1214507A | 1970-12-02 | |||
| GB1292716A | 1972-10-11 | |||
| DE2839033A1 | 1980-03-13 | |||
| GB970588B |
Other References:
JPN6012049742; Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ｖｏｌ．１０３， Ｎｏ．１, 1975, ｐ．１１３-１３４
JPN6012049742; Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ｖｏｌ．１０３， Ｎｏ．１, 1975, ｐ．１１３-１３４
JPN6012049742; Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ｖｏｌ．１０３， Ｎｏ．１, 1975, ｐ．１１３-１３４
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura