Title:
有糸分裂キネシン阻害剤
Document Type and Number:
Japanese Patent JP2007501863
Kind Code:
A
Abstract:
The present invention relates to bicyclic dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Inventors:
Coleman, Paul Jay
Neilson, Lou Ann
Neilson, Lou Ann
Application Number:
JP2006533604A
Publication Date:
February 01, 2007
Filing Date:
June 08, 2004
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D487/04; A01N43/52; A01N43/58; A01N43/60; A01N43/76; A01N43/78; A61K31/138; A61K31/337; A61K31/415; A61K31/4188; A61K31/42; A61K31/424; A61K31/425; A61K31/4465; A61K31/4535; A61K31/495; A61K31/4985; A61K31/50; A61K31/535; A61K31/54; A61K39/395; A61K45/00; A61P1/00; A61P1/18; A61P7/00; A61P11/00; A61P13/00; A61P15/00; A61P35/00; A61P43/00; C07D498/04; A61K
Foreign References:
| WO2001057042A2 | 2001-08-09 | |||
| WO2001057042A2 | 2001-08-09 |
Other References:
JPN6010030696, Ｓ． Ａ． ＡＢＢＡＳ ｅｔ ａｌ．, "Ｓｙｎｔｈｅｓｅ ｄｅ ｍｅｔｈｙｌ−８ ｄｅｈｙｄｒｏ−１，２ ｐｙｒｒｏｌｉｚｉｄｉｎｅｓ ｅｔ ｄｅ ｍｅｔｈｙｌ−９ ｄｅｈｙｄｒｏ−１，２ ｉｎｄｏｌｉｚｉｄｉｎｅｓ", Ｂｕｌｌｅｔｉｎ ｄｅ ｌａ Ｓｏｃｉｅｔｅ Ｃｈｉｍｉｑｕｅ ｄｅ Ｆｒａｎｃｅ, 1986, Ｎｏ．２, ｐ．２８８−２９６
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
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