Title:
MIXED MICELLE
Document Type and Number:
Japanese Patent JPH02289511
Kind Code:
A
Abstract:
PURPOSE: To prepare a formulation for parenteral administration which is in the form of a liposome introduced into lymphatic vessels according to interstitial administration by using a mixed micelle as a carrier. CONSTITUTION: This formulation for parenteral administration, especially intramuscular, subcutaneous or intradermal administration is prepared by including an immunomodulator such as a low-molecular weight active substance having about >10<4> , especially >10<6> partition coefficient in octanol/water and <=10,000, especially 5,000 molecular weight except and oil-soluble vitamin, e.g. (all-E)-3,7- dimethyl-9-(2-trifluoromethyl)-6-(nonyloxy)phenyl-2,4,6,8-nonatetraenoic acid, a cytostatic agent, an antiinfectious agent and a contrast agent in a mixed micelle (a homogeneous aqueous solution of a cholanic acid derivative and a lipid).
Inventors:
UEIN HAIN
ANDOREASU SUUPAASAKUSO
HANSU SUTEFUEN
ANDOREASU SUUPAASAKUSO
HANSU SUTEFUEN
Application Number:
JP6283090A
Publication Date:
November 29, 1990
Filing Date:
March 15, 1990
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K9/107; A61K9/127; A61K45/08; A61K47/28; A61K47/44; A61K31/20; (IPC1-7): A61K9/107; A61K31/20; A61K45/08; A61K47/28; A61K47/44
Attorney, Agent or Firm:
Heikichi Odashima