MMP-2 AND/OR MMP-9 INHIBITOR

Japanese Patent JP2014221839

A

PROBLEM TO BE SOLVED: To provide a highly safe pharmaceutical preparation effective for diseases caused by MMP-2 and/or MMP-9.SOLUTION: The MMP-2 and/or MMP-9 inhibitor contains, as an active ingredient, at least one selected from the group consisting of thiazole derivatives represented by the formula (1), where Rrepresents a phenyl group that may have 1 to 3 lower alkoxy groups as substituents on the phenyl ring, and Rrepresents a pyridyl group that may have 1 to 3 carboxyl groups as substituents on the pyridine ring, and salts thereof.

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MINATOGUCHI SHINYA
ONO YASUSHI
YABUUCHI YOICHI
KOTOSAI KOUNORI
NAGAMOTO TAKASHI

JP2014176705A

November 27, 2014

September 01, 2014

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OTSUKA PHARMA CO LTD

A61K31/4439; A61P1/00; A61P1/02; A61P1/04; A61P3/00; A61P3/10; A61P7/00; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/10; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P19/10; A61P25/00; A61P25/08; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P31/18; A61P33/02; A61P33/06; A61P35/00; A61P35/02; A61P35/04; A61P37/06; A61P37/08; A61P39/02; A61P43/00

WO2008003701A2

2008-01-10

JPN6014009327; Ｍａｒｔｏｒａｎａ，Ｐ．Ａ．，ｅｔ　ａｌ．: '"Ｒｏｆｌｕｍｉｌａｓｔ　Ｆｕｌｌｙ　Ｐｒｅｖｅｎｔｓ　Ｅｍｐｈｙｓｅｍａ　ｉｎ　Ｍｉｃｅ　Ｃｈｒｏｎｉｃａｌｌｙ　Ｅｘｐｏｓｅｄ　ｔｏ　Ｃｉｇａｒｅｔｔｅ　Ｓｍｏｋｅ"' Ａｍ．　Ｊ．　Ｒｅｓｐｉｒ．　Ｃｒｉｔ．　Ｃａｒｅ　Ｍｅｄ． Ｖｏｌ．１７２，Ｎｏ．７, 20051001, ｐｐ．８４８-８５３

Patent business corporation 3 Edakuni [Hajime] patent firm

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