To provide a model animal useful for identifying a molecule for controlling the motility specifically to lymphocyte and elucidating immunity-related diseases such as allergy, autoimmune disease, GvH and graft rejection and morbid states thereof on the molecular level or developing a new therapy thereof.
A model animal, e.g. DOCK2 knockout mouse in which a lymphocyte migration control function is lost or suppressed by deleting DOCK2 gene on a chromosome is prepared. In the DOCK2 knockout mouse, a function for promoting reconstruction of an actin cell skeleton by activating Rac, a migration function of lymphocyte by chemokine stimulation of SLC, SDF-1, BLC, etc., a homing function to a secondary lymph tissue such as spleen, lymph node and Peyer patch and a transfer function of mature thymus T cell into a peripheral blood to ELC Chemokine stimulation are disordered and as a result, immunoresponse is suppressed.
SASAZUKI TAKEHIKO
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