核酸ベクターの改変 - Cyoxus Therapeutics Limited

Title:

核酸ベクターの改変

Document Type and Number:

Japanese Patent JP2012511320

Kind Code:

A

Abstract:

The present invention provides a polymer modified nucleic acid vector in which the nucleic acid vector is covalently linked to a polymer, which polymer comprises one or more positively charged quaternary amino groups, wherein the nucleic acid vector is a micro-organism selected from the group consisting of a virus, a bacteria or a bacteriophage, a fungus, a spore, a eukaryotic cell nucleus or other micro-organism fragment or a component containing genetic information, and wherein (a) the polymer and/or the linkages between it and the nucleic acid vector are hydrolytically, reducibly or enzymatically degradable; and/or (b) wherein each of the positively charged quaternary amino groups is linked to the polymer backbone via one or more degradable or biodegradable linkages.

More Like This:

JP3422995	Description: Recombinant-deficient adenovirus expressing cytokines for antitumor treatment
JP4181300	Modified factors and compositions affecting dorsal tissue
JP2001275683	TRANSFORMED LIVING ORGANISM HAVING HEAVY METAL- ABSORBING CAPABILITY AND METHOD FOR CLEANING HEAVY METAL BY USING THE SAME

Inventors:

Leonard William Sameur
Kelly fisher
Karel Urbrich
Vladimir Subur

Application Number:

JP2011540199A

Publication Date:

May 24, 2012

Filing Date:

December 11, 2009

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Cyoxus Therapeutics Limited

International Classes:

C12N15/09; A61K31/7088; C12N15/63; A61K31/713; A61K35/66; A61K35/74; A61K35/76; A61K36/06; A61K39/00; A61K39/395; A61K45/00; A61K47/32; A61K47/34; A61K47/36; A61K47/48; A61K48/00; C12N15/11; C12N15/86

Foreign References:

WO1995006056A1	1995-03-02
WO2005007798A2	2005-01-27
WO2006085664A1	2006-08-17

Other References:

JPN6014012380; Ｌａｎｇｍｕｉｒｖｏｌ．２４, 200811, ｐｐ．７０９２-７０９８
JPN6014012382; Ｊｏｕｒｎａｌ　ｏｆ　Ｃｏｎｔｒｏｌｌｅｄ　Ｒｅｌｅａｓｅｖｏｌ．８１, 2002, ｐｐ．２０１-２１７
JPN6014012386; Ｂｉｏｃｈｉｍｉｃａ　ｅｔ　Ｂｉｏｐｈｙｓｉｃａ　Ａｃｔａｖｏｌ．１４７５, 2000, ｐｐ．２４５-２５５
JPN5012004921; ＧＲＥＥＮ　Ｎ　Ｋ: 'ＥＸＴＥＮＤＥＤ　ＰＬＡＳＭＡ　ＣＩＲＣＵＬＡＴＩＯＮ　ＴＩＭＥ　ＡＮＤ　ＤＥＣＲＥＡＳＥＤ　ＴＯＸＩＣＩＴＹ　ＯＦ　ＰＯＬＹＭＥＲ-ＣＯＡＴＥＤ　ＡＤＥＮＯＶＩＲＵＳ' ＧＥＮＥ　ＴＨＥＲＡＰＹＶ１１　Ｎ１６, 200408, Ｐ１２５６-１２６３
JPN6014012389; ＴＨＥ　ＪＯＵＲＮＡＬ　ＯＦ　ＧＥＮＥ　ＭＥＤＩＣＩＮＥｖｏｌ．１０, 200801, ｐｐ．４００-４１１
JPN5012004923; ＦＩＳＨＥＲ　Ｋ　Ｄ: 'ＰＯＬＹＭＥＲ-ＣＯＡＴＥＤ　ＡＤＥＮＯＶＩＲＵＳ　ＰＥＲＭＩＴＳ　ＥＦＦＩＣＩＥＮＴ　ＲＥＴＡＲＧＥＴＩＮＧ　ＡＮＤ　ＥＶＡＤＥＳ　ＮＥＵＴＲＡＬＩＳＩＮＧ　ＡＮＴＩＢＯＤＩＥＳ' ＧＥＮＥ　ＴＨＥＲＡＰＹＶ８　Ｎ５, 20010301, Ｐ３４１-３４８, ＭＡＣＭＩＬＬＡＮ　ＰＲＥＳＳ　ＬＴＤ

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Kenji Chatan

Previous Patent: 荷電４級アミノ基を含むポリマーによる核酸ベクターの改変

Next Patent: 免疫賦活性オリゴヌクレオチド