Title:
MODIFICATIONS AND USES OF CONOTOXIN PEPTIDES
Document Type and Number:
Japanese Patent JP2022063872
Kind Code:
A
Abstract:
To provide modifications and uses of conotoxin peptides.SOLUTION: The present disclosure describes analog conotoxin peptides of α-conotoxin peptide RgIA. These analog conotoxin peptides block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) and can be used for treating pain and inflammation including inflammatory pain, cancer related pain, and neuropathic pain. The RgIA analogs in the present invention include a variety of sequence modifications and chemical modifications that are introduced to improve the drug-like characteristics of RgIA analogs and thereby increase their therapeutic value.SELECTED DRAWING: None
Inventors:
JEFFREY JERARD POSAKONY
Application Number:
JP2022010036A
Publication Date:
April 22, 2022
Filing Date:
January 26, 2022
Export Citation:
Assignee:
KINETA CHRONIC PAIN LLC
International Classes:
C07K7/08; A61K38/10; A61K47/54; A61K47/58; A61K47/60; A61K47/61; A61K47/64; A61K47/65; A61K47/68; A61P1/02; A61P1/04; A61P9/00; A61P25/00; A61P25/04; A61P29/00; A61P31/04; C07K14/00; C07K14/435; C07K16/00; C07K19/00
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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