Title:
ウイルス生成ペイロードに対して低い毒性を有する改変ＥＣ７細胞
Document Type and Number:
Japanese Patent JP2021509253
Kind Code:
A
Abstract:
したがって、組換え細胞及び方法は、組換えウイルス、特に複製欠損Ａｄ５ウイルスの迅速且つ高力価な作製を可能にすると考えられる。いくつかの好ましい態様では、宿主細胞は、ウイルス中でコードされる治療用タンパク質の発現を低減又は排除する阻害剤を生成するように改変される一方で、他の態様では、ウイルスは、ウイルス中でコードされる治療用タンパク質の発現を直接的又は間接的に低減又は排除する遺伝子を含む。最も好ましくは、宿主細胞によってコードされるｓｈＲＮＡが、組換えウイルス中でコードされるペイロード遺伝子の発現を低減又は抑制することになる。
Inventors:
Nyazy, Cavan
Tadros, Wael
Shin, Annie
Tadros, Wael
Shin, Annie
Application Number:
JP2020520123A
Publication Date:
March 25, 2021
Filing Date:
October 09, 2018
Export Citation:
Assignee:
Nantes Bio, Inc.
International Classes:
C12N7/00; A61K35/761; A61P35/00; C12N5/071; C12N5/10; C12N15/11; C12N15/113; C12N15/12; C12N15/86; C12N15/861
Domestic Patent References:
| JP2013515731A | 2013-05-09 | |||
| JP2008545406A | 2008-12-18 | |||
| JP2002153278A | 2002-05-28 | |||
| JP2020519294A | 2020-07-02 |
Foreign References:
| WO2005063984A1 | 2005-07-14 | |||
| CN101787373A | 2010-07-28 |
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Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Akiyo Iwahori
Rena Miyoshi
Kaoru Takahashi
Nao Oda
Akiyo Iwahori
Rena Miyoshi
Kaoru Takahashi