Title:
改変第IX因子ポリペプチドおよびその使用
Document Type and Number:
Japanese Patent JP2013500726
Kind Code:
A
Abstract:
The invention relates to modified Factor IX polypeptides such as Factor IX polypeptides with one or more amino acid substitutions. The invention also relates to methods of making modified Factor IX polypeptides, and methods of using modified Factor IX polypeptides, for example, to treat patients afflicted with hemophilia B.
Inventors:
Alan Brooks
Chandra Peter
Xiao Xiao Jiang
Uwe Gritzan
Heiner Apeller
Jun Wan
Chandra Peter
Xiao Xiao Jiang
Uwe Gritzan
Heiner Apeller
Jun Wan
Application Number:
JP2012523129A
Publication Date:
January 10, 2013
Filing Date:
August 02, 2010
Export Citation:
Assignee:
Bayer HealthCare LLC
International Classes:
C12N15/09; A61K38/43; A61P7/04; C07K14/745; C07K19/00; C12N1/15; C12N1/19; C12N5/10
Domestic Patent References:
| JP2007513190A | 2007-05-24 |
Foreign References:
| WO2008118507A2 | 2008-10-02 | |||
| US20080102115A1 | 2008-05-01 |
Other References:
JPN6014043188; Ｓｃｈｕｅｔｔｒｕｍｐｆ ｅｔ ａｌ．: Ｂｌｏｏｄ Ｖｏｌ．１０５， Ｎｏ．６, ｐ．２３１６-２３２３（２００５）
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga