MODIFIED ANNEXIN PROTEINS AND METHOD FOR PREVENTING THROMBOSIS

Japanese Patent JP2008263991

A

To prevent thrombosis without increasing hemorrhage by using a modified annexin protein, preferably annexin V.

The present invention provides a method for screening a modified annexin protein that modulates thrombosis. The method includes: (a) contacting a thrombosis test system with at least one test modified annexin protein under conditions permissive for thrombosis; (b) evaluating antithrombotic activity in the presence of the test modified annexin protein; and (c) comparing the antithrombotic activity in the presence of the test modified annexin protein with the antithrombotic activity in the absence of the test modified annexin protein, wherein a change in the antithrombotic activity in the presence of the test modified annexin protein is indicative of a modified annexin protein that modulates thrombotic activity.

ALLISON ANTHONY

JP2008137728A

November 06, 2008

May 27, 2008

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SURROMED INC

C12Q1/56; G01N33/50; A61K38/00; A61K38/17; A61K47/48; A61P7/02; A61P9/10; C07K1/107; C07K1/113; C07K14/47; C07K16/18; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12Q1/00; G01N33/15; G01N33/86

JP2000504210A	2000-04-11
JPH05508664A	1993-12-02
JP2001500116A	2001-01-09

WO1998031383A1	1998-07-23
US5612460A	1997-03-18

THROMBOSIS RESEARCH, vol. 61, JPN6011009050, 1991, pages 93 - 104, ISSN: 0001852079
THROMBOSIS RESEARCH, vol. 69, JPN6011009049, 1993, pages 289 - 296, ISSN: 0001852080

Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita

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