Title:
改変された抗TNFα抗体
Document Type and Number:
Japanese Patent JP4304073
Kind Code:
B2
Abstract:
This invention pertains to a TNF alpha-binding polypeptide composition comprising at least one of a modified heavy chain variable region polypeptide or a modified light chain variable region polypeptide that is capable of specifically binding to human TNF alpha. The modified heavy and light chain variable region polypeptides of the TNF alpha binding polypeptide are modified by at least one amino acid residue substitution, deletion or addition and are homologous to the heavy and light chain variable regions, respectively, of a non-human monoclonal antibody that specifically binds human TNF alpha. The polypeptide compositions of the invention comprising modified heavy and light chain variable region polypeptides are less immunogenic in a human than are the homologous heavy and light chain variable region polypeptides from a non-human animal.
Inventors:
Helendorn, Cohen
Baker, Matthew
Car, Francis Jay.
Baker, Matthew
Car, Francis Jay.
Application Number:
JP2003544082A
Publication Date:
July 29, 2009
Filing Date:
November 11, 2002
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C07K16/24; A61K38/04; C12N15/09; A61K39/395; A61P1/04; A61P19/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07K7/04; C07K7/08; C07K9/00; C07K16/18; C07K16/46; C07K19/00; C12N15/13; C12P21/08
Foreign References:
| US20010027249 | ||||
| WO1999053038A1 | ||||
| EP0699755A1 | ||||
| WO1998052976A1 | ||||
| WO2000034317A1 | ||||
| WO1992016553A1 |
Attorney, Agent or Firm:
Akio Miyazaki
Katsuhiro Ito
Ishibashi Masayuki
Katsuhiro Ito
Ishibashi Masayuki
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