Title:
増大した活性および細胞膜親和性を有する修飾抗ウイルス性ペプチド
Document Type and Number:
Japanese Patent JP2007531705
Kind Code:
A
Abstract:
The activity and cell membrane affinity of certain antiviral multiple branch peptide constructions, including those known from WO 95/07929, WO 98/29443 and WO 03/95479, can be improved by bonding to the C-end of the peptide a terminator which is either (a) an omega-amino-fatty acid having from 4 to 10 carbon atoms and from 0 to 2 carbon-carbon double bonds or (b) a peptidic cell membrane penetrating agent. The improvement is so marked that in some cases the number of branches can be reduced, sometimes to a single branch, and/or that the branches may be shortened. The preferred omega-amino-fatty acids are gamma-aminobutyric acid, delta-aminovaleric acid and epsilon-aminocaproic acid. The peptidic cell membrane penetrating agent is suitably a TAT-derived peptide, penetratin(R) or Kpam.
Inventors:
Deluge Bonabeth Olivier
Mabrooke Camel
Sabatier Jean-Mare
Mabrooke Camel
Sabatier Jean-Mare
Application Number:
JP2006529908A
Publication Date:
November 08, 2007
Filing Date:
May 20, 2004
Export Citation:
Assignee:
CELLPEP S. A.
International Classes:
C07K14/16; A61K38/00; A61P31/12; C07K4/02; C07K5/083; C07K5/103; C07K5/11; C07K7/00; C07K7/02; A61K39/00; A61K47/48
Domestic Patent References:
| JPH09504273A | 1997-04-28 | |||
| JP2002500175A | 2002-01-08 | |||
| JP2001523647A | 2001-11-27 |
Foreign References:
| WO1998014587A1 | 1998-04-09 | |||
| WO1998029443A1 | 1998-07-09 |
Attorney, Agent or Firm:
Yoshiyasu Takahashi
Tamiwa Iwakura
Takahashi Shoki
Tamiwa Iwakura
Takahashi Shoki