Title:
修飾ブーゲニンタンパク質、サイトトキシン、ならびにそれらの方法および使用
Document Type and Number:
Japanese Patent JP5025460
Kind Code:
B2
Abstract:
The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The invention also provides T-cell epitope peptides of bouganin, and modified T-cell epitope peptides of bouganin which have a reduced propensity to activate human T cells as compared to the non-modified T-cell epitope peptide. The invention also provides cytotoxins having the having a ligand that binds to a cancer cells attached to the modified bouganin proteins. Also provided are methods of inhibiting or destroying mammalian cancer cells using the cytotoxins of the invention and pharmaceutical compositions for treating human cancer.
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Inventors:
Baker Matthew
Car Francis Jay.
Helen Dawn Cohen
Shizu Genic
McDonald Glen Christopher
Entwistle Joycelyn
Bosque Dennis Georges
Glover Nicolas Ronald
Car Francis Jay.
Helen Dawn Cohen
Shizu Genic
McDonald Glen Christopher
Entwistle Joycelyn
Bosque Dennis Georges
Glover Nicolas Ronald
Application Number:
JP2007503165A
Publication Date:
September 12, 2012
Filing Date:
March 18, 2005
Export Citation:
Assignee:
Merck Patent Game Behr
International Classes:
C12N15/09; A61K38/00; A61K38/16; A61K39/395; A61K47/48; A61P35/00; C07K7/08; C07K14/415; C07K16/30; C07K16/44; C07K19/00; C12N15/11; C12N15/13; C12N15/29; C12N15/62
Foreign References:
| WO2005121341A1 | ||||
| WO1998055623A1 | ||||
| US6680296 | ||||
| WO1998058678A1 | ||||
| WO2003103715A1 | ||||
| US6680295 |
Other References:
DEN HARTOG, M.T. et al.,"Cloning and expression of cDNA coding for bouganin.",EUR. J. BIOCHEM.,2002年 3月,Vol.269, No.6,P.1772-1779
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi