Title:
改変カスパーゼ－９ポリペプチドおよびその使用方法
Document Type and Number:
Japanese Patent JP7261232
Kind Code:
B2
Abstract:
Provided herein are modified caspase-9 polypeptides, and chimeric caspase-9 proteins containing the modified caspase-9 polypeptides. The disclosure further provides polynucleotides encoding these proteins, engineered host cells containing these polynucleotides and proteins, including host cells that co-express a chimeric antigen receptor, and methods of making and using the same.
Inventors:
Galindo Casas Meritsel
Bambracom Thomas John
Bambracom Thomas John
Application Number:
JP2020524246A
Publication Date:
April 19, 2023
Filing Date:
October 31, 2018
Export Citation:
Assignee:
Alogin Therapeutics, Incorporated
International Classes:
C12N15/57; C07K19/00; C12N5/0783; C12N5/10; C12N9/50; C12N15/10; C12N15/62; C12N15/63
Foreign References:
| WO2015134877A1 |
Other References:
PING LI; ET AL,CASPASE-9: STRUCTURE, MECHANISMS AND CLINICAL APPLICATION,ONCOTARGET,2017年04月04日,VOL:8, NR:14,PAGE(S):23996 - 24008,http://dx.doi.org/10.18632/oncotarget.15098
Attorney, Agent or Firm:
Shinichiro Tanaka
Yoshi Kazuhiko Ta
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Yoshi Kazuhiko Ta
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori