Title:
Blimp1およびレポーター分子を共発現する改変細胞およびその使用方法
Document Type and Number:
Japanese Patent JP4890269
Kind Code:
B2
Abstract:
In one aspect, the present invention provides a genetically modified cell or non-human organism comprising such cells comprising modified genetic material which when expressed produces a polypeptide co-expressed with a reporter molecule and wherein the polypeptide is associated with terminal differentiation of a haematopoietic cell. Preferably, the genetic material gene is a Blimp allele or a part, fragment or functional form thereof. Furthermore, the identification of the reporter molecule in B-cell lineage cells indicates that such cells are committed to differentiate or have differentiated into ASC. Alternatively, reporter molecule activity in cells of a T cell lineage indicates that these cells are activated. Thus, as described herein, the presence of Blimp in a lymphocyte indicates that the cell is terminally differentiated or is committed to terminal differentiation. Exemplary T-cells include CD4+ T-cells and CD8+ T-cells and exemplary B-cells are ASC.
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Inventors:
Curry axel
Hasbold Jagvaral
Tarrington david
Corcoran phosphorus
Hodgkin Philip Desmond
Nat Stefan Lawrence
Hasbold Jagvaral
Tarrington david
Corcoran phosphorus
Hodgkin Philip Desmond
Nat Stefan Lawrence
Application Number:
JP2006552420A
Publication Date:
March 07, 2012
Filing Date:
February 11, 2005
Export Citation:
Assignee:
Walter and Eliza Hall Institute of Medical Research
International Classes:
C12N15/09; A01K67/027; C12N5/10; C12N15/12; C12N15/63; C12N15/85; C12N15/90; C12Q1/02; G01N21/78; G01N33/15; G01N33/49; G01N33/50
Domestic Patent References:
| JP2001523467A | 2001-11-27 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto