Title:
低減された免疫原性を有する修飾されたエリスロポエチン(EPO)
Document Type and Number:
Japanese Patent JP2004522445
Kind Code:
A
Abstract:
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The inention in particular relates to the modification of erythropoietin (EPO) to result in erythropoietin proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.
Inventors:
Car, Francis, Jay.
Carter, Graham
Jones, Tim
Williams, Stephen
Carter, Graham
Jones, Tim
Williams, Stephen
Application Number:
JP2002563195A
Publication Date:
July 29, 2004
Filing Date:
February 05, 2002
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
A61K9/70; A61K38/18; A61K38/27; A61K47/02; A61K47/12; A61P7/00; A61P7/06; C12N15/09; C07K7/06; C07K7/08; C07K14/505; C07K14/54; C07K16/18; C07K16/28; C07K16/30; C07K16/46; C12N15/18; C12P21/02; G06F17/30; G16B15/20; G16B20/00; A61K38/00; (IPC1-7): C12N15/09; A61K38/27; A61P7/00; A61P7/06; C07K7/08; C07K14/505; C12P21/02; G06F17/30
Attorney, Agent or Firm:
Akio Miyazaki
Nobuyuki Kaneda
Katsuhiro Ito
Ishibashi Masayuki
Nobuyuki Kaneda
Katsuhiro Ito
Ishibashi Masayuki