Title:
改変モルビリウイルスタンパク質
Document Type and Number:
Japanese Patent JP2004513616
Kind Code:
A
Abstract:
Modified Morbilliviruses having at least one mutation in the region corresponding to amino acids 112-134 of the measles virus V protein are described, wherein one or both of amino acids 113 or 114 is mutated. Such modified Morbilliviruses exhibit reduced repression of gene expression. Additional mutations or deletions in other regions of the genome may be included, including in the carboxy-terminal region.
Inventors:
Parks, Christopher El
Application Number:
JP2002505816A
Publication Date:
May 13, 2004
Filing Date:
June 21, 2001
Export Citation:
Assignee:
Wyeth Holdings Corporation
International Classes:
C12N15/09; A61K39/155; A61K39/165; C07K14/12; C12N7/00; C12N7/02; C12N7/04; (IPC1-7): C12N15/09; A61K39/155; C12N7/00; C12N7/02
Foreign References:
| WO1999049017A2 | 1999-09-30 | |||
| WO1998013501A2 | 1998-04-02 |
Attorney, Agent or Firm:
Heikichi Odashima