Title:
MODIFIED OLIGONUCLEOTIDE FOR TELOMERASE INHIBITION
Document Type and Number:
Japanese Patent JP2012085648
Kind Code:
A
Abstract:
To provide modified oligonucleotides for telomerase inhibition.
Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics. This means that an equivalent biological effect may be obtained using smaller amounts of the conjugated oligonucleotide compared to an unmodified form. The compositions and methods relate to telomerase inhibiting compounds comprising an oligonucleotide and at least one covalently linked lipid group.
Inventors:
GRYAZNOV SERGEI
PONGRACZ KRISZTINA
PONGRACZ KRISZTINA
Application Number:
JP2011274595A
Publication Date:
May 10, 2012
Filing Date:
December 15, 2011
Export Citation:
Assignee:
GERON CORP
International Classes:
C12N15/115; A01N43/04; A61K31/7105; A61K31/7125; A61K47/48; A61K48/00; A61P35/00; A61P35/02; A61P43/00; C07H21/02; C07H21/04; C12N5/00; C12N15/113; C12N9/99; C12N
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita