To provide a method of conjugating peptides and proteins by means of glycosyltransferase.
It is an object of the invention to provide means and methods which allow for a convenient synthesis or semisynthesis of therapeutic proteins, where the introduction of the modification addresses the problem. The present invention provides for the prolongation of the circulating half-life of soluble glycoprotein derivatives, thus reducing the quality of injected material and frequency of injection required for maintenance of therapeutically effective levels of circulating glycoprotein for treatment or prophylaxis. The short in vivo plasma half-life of certain therapeutically active glycoproteins is undesirable due to the frequency and the amount of soluble protein which would be required in treatment or prophylaxis. The present invention provides means to prolong the circulating half-life of such glycoproteins with an effective change to the glycoprotein structure and with the substantial maintenance of biological activity.
GARIBAY PATRICK WILLIAM
MAGALI ZUNDEL
| JPH07111895A | 1995-05-02 |
| WO2003046150A2 | 2003-06-05 | |||
| WO2004000366A1 | 2003-12-31 |
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Yoshihiro Fukuhara
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Naoki Kono
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Takashi Okada
Mihoko Horiuchi
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