Title:
MODULAR PARTICLES FOR IMMUNOTHERAPY
Document Type and Number:
Japanese Patent JP2022078345
Kind Code:
A
Abstract:
To provide modular particles for immunotherapy.SOLUTION: Nanoparticulate compositions are disclosed. The nanoparticulate compositions typically include at least one, preferably two or more, active agents, one of which is an immunomodulatory compound, loaded into, attached to the surface of and/or enclosed within a delivery vehicle. The delivery vehicles can be nanolipogels including a polymeric core and a lipid shell or a biodegradable polymeric nanoparticle such as a PLGA nanoparticle. Typically, at least one of the active agents is an immunomodulator that increases an immune stimulatory response or decreases an immune suppressive response. In some embodiments, the particle includes both an immunomodulator that increases an immune stimulatory response and an immunomodulator that decreases an immune suppressive response. The particles can be decorated with a targeting moiety that improves delivery to a target cell.SELECTED DRAWING: None
Inventors:
TAREK M FAHMY
BRIAN HORSBURGH
BRIAN HORSBURGH
Application Number:
JP2022043714A
Publication Date:
May 24, 2022
Filing Date:
March 18, 2022
Export Citation:
Assignee:
UNIV YALE
International Classes:
A61K45/06; A61K9/127; A61K9/14; A61K31/4178; A61K31/4439; A61K38/19; A61K38/20; A61K38/21; A61P35/00; A61P37/02; A61P43/00
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki
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